通过磁共振荧光透视法证明茶碱治疗对慢性阻塞性肺疾病患者膈肌运动的影响。
Demonstrating the effect of theophylline treatment on diaphragmatic movement in chronic obstructive pulmonary disease patients by MR-fluoroscopy.
作者信息
Etlik Omer, Sakarya M Emin, Uzun Kursat, Harman Mustafa, Temizoz Osman, Durmus Ahmet
机构信息
Department of Radiology, Yüzüncü Yil University, Faculty of Medicine, Van 65200, Turkey.
出版信息
Eur J Radiol. 2004 Aug;51(2):150-4. doi: 10.1016/S0720-048X(03)00210-9.
INTRODUCTION
The purpose of this study was to determine the increase in diaphragmatic excursion of patients with chronic obstructive pulmonary disease (COPD) treated with theophylline by MR-fluoroscopy which is an innovative method to demonstrate effectiveness of this treatment.
MATERIALS AND METHODS
Investigations were performed on a 0.3 T open MR unit. MR-fluoroscopy images of 30 patients with COPD were obtained before and after theophylline treatment. Diaphragmatic movement values were recorded for evaluation.
RESULTS
The response of the diaphragmatic movement in COPD patients treated with theophylline was evaluated by MR-fluoroscopy and an increase of 48% in diaphragmatic contractility was determined after the treatment. The increase in contractility was found to be parallel with respiratory function tests and clinical status.
CONCLUSION
Diaphragmatic movement and response to the medical therapy in patients with COPD can be evaluated by MR-fluoroscopy method which can allow accurate measurements.
引言
本研究的目的是通过磁共振荧光透视法确定接受茶碱治疗的慢性阻塞性肺疾病（COPD）患者膈肌活动度的增加情况，这是一种证明该治疗效果的创新方法。
材料与方法
在一台0.3T开放式磁共振设备上进行研究。对30例COPD患者在茶碱治疗前后获取磁共振荧光透视图像。记录膈肌运动值以进行评估。
结果
通过磁共振荧光透视法评估了接受茶碱治疗的COPD患者膈肌运动的反应，治疗后膈肌收缩力增加了48%。发现收缩力的增加与呼吸功能测试和临床状况平行。
结论
磁共振荧光透视法可用于评估COPD患者的膈肌运动及对药物治疗的反应，该方法能够进行准确测量。
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