转录网络：在全球范围内反向工程基因调控

Transcriptional networks: reverse-engineering gene regulation on a global scale.

作者信息

Chua Gordon, Robinson Mark D, Morris Quaid, Hughes Timothy R

机构信息

Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Room 307, Toronto, Ontario M5G 1L6, Canada.

出版信息

Curr Opin Microbiol. 2004 Dec;7(6):638-46. doi: 10.1016/j.mib.2004.10.009.

DOI:10.1016/j.mib.2004.10.009

PMID:15556037

Abstract

A major objective in post-genome research is to fully understand the transcriptional control of each gene and the targets of each transcription factor. In yeast, large-scale experimental and computational approaches have been applied to identify co-regulated genes, cis regulatory elements, and transcription factor DNA binding sites in vivo. Methods for modeling and predicting system behavior, and for reconciling discrepancies among data types, are being explored. The results indicate that a complete and comprehensive yeast transcriptional network will ultimately be achieved.

摘要

后基因组研究的一个主要目标是全面了解每个基因的转录调控以及每个转录因子的靶标。在酵母中，大规模实验和计算方法已被用于在体内鉴定共调控基因、顺式调控元件和转录因子DNA结合位点。正在探索用于建模和预测系统行为以及协调数据类型之间差异的方法。结果表明，最终将实现一个完整且全面的酵母转录网络。