如何拆解雷管突触。

How to dismantle a detonator synapse.

作者信息

Pelkey Kenneth A, McBain Chris J

机构信息

Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 35, Bethesda, MD 20892, USA.

出版信息

Neuron. 2005 Feb 3;45(3):327-9. doi: 10.1016/j.neuron.2005.01.018.

DOI:10.1016/j.neuron.2005.01.018

PMID:15694316

Abstract

Direct electrophysiological evaluation of ion channels in vertebrate presynaptic nerve terminals has been limited to synapses such as the neuromuscular junction and the giant calyx of Held. In this issue of Neuron, Engel and Jonas demonstrate that mossy fiber boutons have specialized voltage-gated Na(+) channels that critically impact upon presynaptic Ca(2+) influx by amplifying terminal invading action potentials.

摘要

对脊椎动物突触前神经末梢离子通道的直接电生理评估一直局限于神经肌肉接头和Held巨突触等突触。在本期《神经元》杂志中，恩格尔和乔纳斯证明，苔藓纤维终扣具有特殊的电压门控钠通道，这些通道通过放大终末侵入动作电位，对突触前钙内流产生关键影响。