Piangatelli C, De Angelis C, Pecora L, Recanatini F, Testasecca D
Unit of Anesthesia and Resuscitation, Umberto I Hospital, Ancona, Italy.
Minerva Anestesiol. 2004 Dec;70(12):801-7.
The aim of this study was to compare the clinical profiles of psoas block and sciatic nerve block performed with either 0.5% levobupivacaine or 0.75% ropivacaine.
With ethical committee approval and written informed consent 80 ASA physical status I-II patients, undergoing lower extremity surgery received intravenous premedication with midazolam (0.05 mg/kg) and atropine (0.01 mg/kg). Patients were randomly allocated to receive a lumbar plexus block with: Levobupivacaine Group (L) 30 ml of 0.5% levobupivacaine or Ropivacaine Group (R) 0.75% ropivacaine, and sciatic nerve block with: Group R 10 ml 0.75 ropivacaine or Group L 0.5% levobupivacaine. The onset time and duration of nerve block were evaluated.
The motor onset time was shorter in Group L than in Group R. The motor offset time was similar in the 2 groups, the time being slightly greater for Group R. Group L presented a higher difference of resolution to motor-sensitive block compared to Group R.
The differences between Groups L and R were characterised by: a faster motor onset time in Group L with a longer time between motor and sensitive resolution determining a lower demand for analgesic drugs postoperatively and greater support for motor control recovery.
本研究旨在比较用0.5%左旋布比卡因或0.75%罗哌卡因进行腰大肌阻滞和坐骨神经阻滞的临床特征。
经伦理委员会批准并获得书面知情同意后,80例接受下肢手术的美国麻醉医师协会(ASA)身体状况I-II级患者,静脉注射咪达唑仑(0.05 mg/kg)和阿托品(0.01 mg/kg)进行术前用药。患者被随机分配接受以下腰丛阻滞:左旋布比卡因组(L组),30 ml 0.5%左旋布比卡因;或罗哌卡因组(R组),0.75%罗哌卡因;以及以下坐骨神经阻滞:R组,10 ml 0.75%罗哌卡因;或L组,0.5%左旋布比卡因。评估神经阻滞的起效时间和持续时间。
L组的运动起效时间比R组短。两组的运动消退时间相似,R组稍长。与R组相比,L组在运动敏感阻滞消退方面的差异更大。
L组和R组之间的差异表现为:L组运动起效时间更快,运动和感觉消退之间的时间更长,这决定了术后对镇痛药的需求更低,对运动控制恢复的支持更大。