伏立康唑对念珠菌属的潜在杀菌作用
Potential fungicidal effect of voriconazole against Candida spp.
作者信息
Rubio M Carmen, de Ocáriz Inmaculada Ramírez, Gil Joaquina, Benito Rafael, Rezusta Antonio
机构信息
Microbiology, Hospital Clínico Universitario Lozano Blesa, Domingo Miral s/n, Zaragoza 50009, Spain.
出版信息
Int J Antimicrob Agents. 2005 Mar;25(3):264-7. doi: 10.1016/j.ijantimicag.2004.11.007.
In vitro fungistatic and fungicidal activities of voriconazole were evaluated against 114 isolates of Candida spp. MICs were determined using the NCCLS M27-A2 broth microdilution method. Minimum fungicidal concentrations (MFCs) were defined as the lowest drug concentrations that yielded < or = 5 colonies (> or = 98% killing activity). The fungicidal activity could be only evaluated against 45.6% of the isolates (52 of 114 isolates) because trailing growth occurred, and 30 of these 52 isolates (57.69%) showed MFC values < or = 1 mg/l. There was little or no fungicidal activity against C. albicans and C. tropicalis. In contrast, all C. krusei were killed by 1-2 mg/l voriconazole. In conclusion, our data show that the fungicidal effect of voriconazole against Candida spp. is species dependent.
对伏立康唑针对114株念珠菌属菌株的体外抑菌和杀菌活性进行了评估。采用NCCLS M27 - A2肉汤微量稀释法测定最低抑菌浓度（MIC）。最低杀菌浓度（MFC）定义为产生≤5个菌落（≥98%杀灭活性）的最低药物浓度。由于出现拖尾生长，仅能对45.6%的菌株（114株中的52株）评估杀菌活性，这52株中的30株（57.69%）的MFC值≤1mg/L。对白色念珠菌和热带念珠菌几乎没有杀菌活性。相比之下，所有克柔念珠菌在1 - 2mg/L伏立康唑作用下均被杀死。总之，我们的数据表明伏立康唑对念珠菌属的杀菌作用具有种属依赖性。
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