老年BALB/c小鼠作为老年人严重急性呼吸综合征病情加重的模型。
Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans.
作者信息
Roberts Anjeanette, Paddock Christopher, Vogel Leatrice, Butler Emily, Zaki Sherif, Subbarao Kanta
机构信息
LID, NIAID, NIH, 50 South Dr., Room 6351, MSC 8007, Bethesda, MD 20892, USA.
出版信息
J Virol. 2005 May;79(9):5833-8. doi: 10.1128/JVI.79.9.5833-5838.2005.
Abstract
Advanced age has repeatedly been identified as an independent correlate of adverse outcome and a predictor of mortality in cases of severe acute respiratory syndrome (SARS). SARS-associated mortality may exceed 50% for persons aged 60 years or older. Heightened susceptibility of the elderly to severe SARS and the ability of SARS coronavirus to replicate in mice led us to examine whether aged mice might be susceptible to disease. We report here that viral replication in aged mice was associated with clinical illness and pneumonia, demonstrating an age-related susceptibility to SARS disease in animals that parallels the human experience.
摘要
高龄反复被确认为严重急性呼吸综合征（SARS）病例不良结局的独立相关因素和死亡率的预测指标。60岁及以上人群中与SARS相关的死亡率可能超过50%。老年人对严重SARS的易感性增加以及SARS冠状病毒在小鼠体内复制的能力促使我们研究老年小鼠是否易患该病。我们在此报告，老年小鼠体内的病毒复制与临床疾病和肺炎相关，这表明动物对SARS疾病的易感性与年龄相关，与人类情况相似。
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