硼导向的区域和立体选择性烯炔交叉复分解反应：含1,3-二烯的硼酸乙烯酯的高效合成

Boron-directed regio- and stereoselective enyne cross metathesis: efficient synthesis of vinyl boronate containing 1,3-dienes.

作者信息

Kim Mansuk, Lee Daesung

机构信息

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

出版信息

Org Lett. 2005 Apr 28;7(9):1865-8. doi: 10.1021/ol050542r.

DOI:10.1021/ol050542r

PMID:15844926

Abstract

[reaction: see text] Regio- and stereoselective enyne cross metathesis reactions between borylated alkynes and terminal alkenes were realized to provide a variety of functionalized vinyl boronates. High chemical yield and regioselectivity was achieved irrespective of substituents on the alkyne and alkene counterparts, whereas Z/E-selectivity was found to be dependent upon the substituents both on the alkyne and alkene.

摘要

[反应：见正文] 实现了硼化炔烃与末端烯烃之间的区域和立体选择性烯炔交叉复分解反应，以提供各种官能化的乙烯基硼酸酯。无论炔烃和烯烃对应物上的取代基如何，都能实现高化学产率和区域选择性，而Z/E选择性则取决于炔烃和烯烃上的取代基。