阿根廷传统药用植物的体外抗真菌试验。

In vitro antifungal assay of traditional Argentine medicinal plants.

作者信息

Muschietti Liliana, Derita Marcos, Sülsen Valeria, de Dios Muñoz Juan, Ferraro Graciela, Zacchino Susana, Martino Virginia

机构信息

Cátedra de Farmacognosia, IQUIMEFA (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113), Buenos Aires, Argentina.

出版信息

J Ethnopharmacol. 2005 Nov 14;102(2):233-8. doi: 10.1016/j.jep.2005.06.017. Epub 2005 Aug 1.

DOI:10.1016/j.jep.2005.06.017

PMID:16055292

Abstract

Methanol extracts from 11 traditionally used Argentine medicinal plants were assayed in vitro for antifungal activity against yeasts, hialohyphomycetes as well as dermatophytes with the microbroth dilution method. Among them, the strongest effect was presented by Eupatorium buniifolium and Terminalia triflora, Trichophyton mentagrophytes and Trichophyton rubrum being the most susceptible species with MICs ranging from 100 to 250 microg/ml. Lithrea molleoides showed the broadest spectrum of action inhibiting all of the tested dermatophytes with MIC=250 microg/ml.

摘要

采用微量肉汤稀释法，对11种阿根廷传统药用植物的甲醇提取物进行体外抗真菌活性测定，测试对象包括酵母、丝状真菌以及皮肤癣菌。其中，牛膝菊和三叶榄仁的效果最强，须癣毛癣菌和红色毛癣菌是最敏感的菌种，其最低抑菌浓度（MIC）范围为100至250微克/毫升。软毛石梓表现出最广的抗菌谱，对所有测试的皮肤癣菌均有抑制作用，MIC = 250微克/毫升。