强迫症（OCD）患者在接受西酞普兰治疗时血清素转运体（SERT）和多巴胺转运体（DAT）的可用性。
SERT and DAT availabilities under citalopram treatment in obsessive-compulsive disorder (OCD).
作者信息
Pogarell Oliver, Poepperl Gabriele, Mulert Christoph, Hamann Christine, Sadowsky Nikolai, Riedel Michael, Moeller Hans-Juergen, Hegerl Ulrich, Tatsch Klaus
机构信息
Department of Psychiatry, Section of Clinical Neurophysiology, Ludwig-Maximilians-University of Munich, Nussbaumstr. 7, D-80336 Munich, Germany.
出版信息
Eur Neuropsychopharmacol. 2005 Oct;15(5):521-4. doi: 10.1016/j.euroneuro.2005.01.003.
Serotonin and dopamine transporter (SERT, DAT) availabilities have prospectively been investigated using [123I]beta-CIT and single photon emission computed tomography in subjects with obsessive-compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain.
在接受选择性5-羟色胺再摄取抑制剂西酞普兰治疗的强迫症患者中，已使用[123I]β-CIT和单光子发射计算机断层扫描对5-羟色胺和多巴胺转运体（SERT、DAT）的可用性进行了前瞻性研究。SERT可用性平均降低了36.5%，而DAT可用性增加了约40%。这些数据表明西酞普兰可诱导5-羟色胺能和多巴胺能活性的调节，并支持人脑单胺能系统功能相互作用的观点。
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