在急性髓系白血病中应用免疫突触：用于主动特异性免疫的白血病树突状细胞的开发。

Employing the immunological synapse in AML: development of leukemic dendritic cells for active specific immunization.

作者信息

Houtenbos Ilse, Westers Theresia M, Ossenkoppele Gert J, van de Loosdrecht Arjan A

机构信息

Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

出版信息

Immunobiology. 2005;210(2-4):249-57. doi: 10.1016/j.imbio.2005.05.019.

DOI:10.1016/j.imbio.2005.05.019

PMID:16164032

Abstract

Cytotoxic T cells directed against leukemic blasts have been observed in patients with acute myeloid leukemia (AML). However, generation of efficient T-cell responses is hampered due to several factors that enable AML blasts to protect themselves from the patients immune system. Improved immune responses can be established by the differentiation of AML blasts into AML-derived dendritic cells (DC) thereby conserving their intrinsic leukemia specific antigens and obtaining full capacity to present these antigens to naive T cells. This review discusses increased immunogenicity of AML blasts by differentiation into AML-DC and describes ways to augment the AML-DC vaccination approach.

摘要

在急性髓系白血病（AML）患者中已观察到针对白血病母细胞的细胞毒性T细胞。然而，由于多种因素使AML母细胞能够保护自身免受患者免疫系统攻击，高效T细胞反应的产生受到阻碍。通过将AML母细胞分化为AML来源的树突状细胞（DC），可以建立更强的免疫反应，从而保留其内在的白血病特异性抗原，并获得将这些抗原呈递给幼稚T细胞的全部能力。本文综述了AML母细胞分化为AML-DC后免疫原性的增强，并描述了增强AML-DC疫苗接种方法的途径。