甜叶菊的抗炎活性。

Anti-inflammatory activity of Lippia dulcis.

作者信息

Pérez S, Meckes M, Pérez C, Susunaga A, Zavala M A

机构信息

Depto Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, A.P. 23-181, México D.F., Mexico.

出版信息

J Ethnopharmacol. 2005 Oct 31;102(1):1-4. doi: 10.1016/j.jep.2005.06.047.

DOI:10.1016/j.jep.2005.06.047

PMID:16169695

Abstract

Lippia dulcis hexane and ethanol extracts were tested for its anti-inflammatory activity in several animal models. Hexane extract showed to be inactive, but the ethanol extract at doses of 400 mg/kg produced significant inhibition of carrageenan-induced paw oedema and reduced the weight of cotton pellet-induced granuloma, moreover, the topical application of 0.5 mg/ear of this extract inhibited the edema induced with TPA by 49.13%, an effect which is of less intensity than that produced by indomethacine at the same dose.

摘要

对甜薄荷的己烷和乙醇提取物在几种动物模型中进行了抗炎活性测试。己烷提取物显示无活性，但400mg/kg剂量的乙醇提取物对角叉菜胶诱导的爪肿胀产生了显著抑制作用，并减轻了棉球诱导的肉芽肿重量。此外，该提取物以0.5mg/耳的剂量局部应用时，对TPA诱导的水肿的抑制率为49.13%，其效果强度低于相同剂量的吲哚美辛所产生的效果。