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糖尿病足部溃疡治疗后的无溃疡生存期

Ulcer-free survival following management of foot ulcers in diabetes.

作者信息

Pound N, Chipchase S, Treece K, Game F, Jeffcoate W

机构信息

Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham, UK.

出版信息

Diabet Med. 2005 Oct;22(10):1306-9. doi: 10.1111/j.1464-5491.2005.01640.x.

Abstract

AIMS

Measures of healing rate may not give a complete indication of the effectiveness of overall management of diabetic foot ulcers. Apart from healing and speed of healing, the outcomes of greatest importance to the patient are avoidance of any amputation and remaining free from any recurrence. We have documented the number of patients presenting with diabetic foot ulcers who become ulcer free and examined the value of documenting ulcer-free survival.

METHODS

All referrals to a specialist diabetic foot clinic over a 31-month period were analysed and outcomes were determined after a minimum follow-up of 6 months.

RESULTS

Three hundred and seventy patients were referred with a total of 1031 ulcers. One hundred and twenty-one (32.7%) never became ulcer free: 56 (46.3% of 121) remained unhealed, the ulcers of 12 (9.9% of 121) had been resolved by amputation, two remained unhealed after amputation (1.7% of 121) and 51 (13.8% of 370) had died. Two hundred and thirty-one (62.4% of 370) became ulcer free at some stage. Five of these were excluded because of an earlier amputation. Ninety-one of the remaining 226 (40.3%) developed a recurrent or new ulcer after a median 126 days. Of the 135 who did not have a recurrence, 133 (58.8% of 226; 35.9% of 370) survived ulcer free and with limbs intact, while two died. Outcome was unknown in 18 (4.9%). Those who never became ulcer free were older (P < 0.001) and with a greater prevalence of ischaemia (P < 0.001). Those who healed but went on to suffer a new ulcer had a greater prevalence of neuropathy (P = 0.027) than those who remained ulcer free.

CONCLUSIONS

The use of ulcer-free survival can be used as an indication of the effectiveness of foot ulcer management. It could be adopted as a measure to compare performance between different specialist units.

摘要

目的

愈合率指标可能无法全面反映糖尿病足溃疡整体治疗的效果。除了愈合情况和愈合速度外,对患者最重要的结果是避免任何截肢以及不再复发。我们记录了糖尿病足溃疡患者实现溃疡愈合的人数,并研究了记录无溃疡生存期的价值。

方法

对31个月内转诊至糖尿病足专科门诊的所有患者进行分析,并在至少随访6个月后确定结果。

结果

共转诊370例患者,总计1031处溃疡。121例(32.7%)从未实现溃疡愈合:56例(121例中的46.3%)仍未愈合,12例(121例中的9.9%)的溃疡通过截肢得以解决,2例截肢后仍未愈合(121例中的1.7%),51例(370例中的13.8%)死亡。231例(370例中的62.4%)在某个阶段实现了溃疡愈合。其中5例因早期截肢被排除。其余226例中的91例(40.3%)在中位时间126天后出现复发性或新的溃疡。在135例未复发的患者中,133例(226例中的58.8%;370例中的35.9%)存活且无溃疡,肢体完整,2例死亡。18例(4.9%)的结局未知。从未实现溃疡愈合的患者年龄更大(P<0.001),缺血患病率更高(P<0.001)。愈合但随后出现新溃疡的患者神经病变患病率高于未复发的患者(P=0.027)。

结论

无溃疡生存期可作为评估足部溃疡治疗效果的指标。它可被用作比较不同专科单位治疗效果的一项衡量标准。

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