CARMA1的磷酸化：与核因子-κB激活的联系

Phosphorylation of CARMA1: the link(er) to NF-kappaB activation.

作者信息

Rueda Daniel, Thome Margot

机构信息

Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.

出版信息

Immunity. 2005 Dec;23(6):551-3. doi: 10.1016/j.immuni.2005.11.007.

DOI:10.1016/j.immuni.2005.11.007

PMID:16356853

Abstract

Antigen receptor-induced NF-kappaB activation depends on receptor-proximal and -distal signaling events. Two papers in this issue of Immunity demonstrate that PKC-dependent phosphorylation of CARMA1 is the critical molecular link that controls the activation of the IKK signalosome and NF-kappaB.

摘要

抗原受体诱导的核因子-κB激活取决于受体近端和远端的信号转导事件。本期《免疫》杂志上的两篇论文表明，CARMA1的蛋白激酶C依赖性磷酸化是控制IKK信号小体和核因子-κB激活的关键分子环节。