富含AU元件及其相关因子：是否存在统一的原则？
AU-rich elements and associated factors: are there unifying principles?
作者信息
Barreau Carine, Paillard Luc, Osborne H Beverley
机构信息
UMR 6061 CNRS Génétique et Développement, IFR 140 Génétique Fonctionnelle Agronomie et Santé, Université de Rennes 1, Faculté de Médecine, CS 34317, 35043 Rennes cedex, France.
出版信息
Nucleic Acids Res. 2006 Jan 3;33(22):7138-50. doi: 10.1093/nar/gki1012. Print 2005.
The control of mRNA stability is an important process that allows cells to not only limit, but also rapidly adjust, the expression of regulatory factors whose over expression may be detrimental to the host organism. Sequence elements rich in A and U nucleotides or AU-rich elements (AREs) have been known for many years to target mRNAs for rapid degradation. In this survey, after briefly summarizing the data on the sequence characteristics of AREs, we present an analysis of the known ARE-binding proteins (ARE-BP) with respect to their mRNA targets and the consequences of their binding to the mRNA. In this analysis, both the changes in mRNA stability and the lesser studied effects on translation are considered. This analysis highlights the multitude of mRNAs bound by one ARE-BP and conversely the large number of ARE-BP that associate with any particular ARE-containing mRNA. This situation is discussed with respect to functional redundancies or antagonisms. The potential relationship between mRNA stability and translation is also discussed. Finally, we present several hypotheses that could unify the published data and suggest avenues for future research.
mRNA稳定性的控制是一个重要过程，它使细胞不仅能够限制，而且能够快速调节调控因子的表达，这些调控因子的过度表达可能对宿主生物体有害。富含A和U核苷酸的序列元件或富含AU的元件（AREs）多年来一直被认为是导致mRNA快速降解的靶点。在本综述中，在简要总结AREs序列特征的数据后，我们对已知的ARE结合蛋白（ARE-BP）进行了分析，涉及它们的mRNA靶点以及它们与mRNA结合的后果。在该分析中，既考虑了mRNA稳定性的变化，也考虑了对翻译影响较小的研究。该分析突出了一个ARE-BP所结合的众多mRNA，反之亦然，即与任何特定含ARE的mRNA相关联的大量ARE-BP。针对功能冗余或拮抗作用对这种情况进行了讨论。还讨论了mRNA稳定性与翻译之间的潜在关系。最后，我们提出了几个可以统一已发表数据的假设，并为未来的研究指明了方向。
Zotero 插件