泰国不同禽类近期流感病毒分离株血凝素和神经氨酸酶基因的特征分析
Characterization of the hemagglutinin and neuraminidase genes of recent influenza virus isolates from different avian species in Thailand.
作者信息
Keawcharoen J, Amonsin A, Oraveerakul K, Wattanodorn S, Papravasit T, Karnda S, Lekakul K, Pattanarangsan R, Noppornpanth S, Fouchier R A M, Osterhaus A D M E, Payungporn S, Theamboonlers A, Poovorawan Y
机构信息
Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
出版信息
Acta Virol. 2005;49(4):277-80.
The hemagglutinin (HA) and neuraminidase (NA) genes of eight influenza A virus (H5N1) isolates obtained from various avian species in Thailand in 2003-2004 have been characterized in comparison with the Thai isolate A/Chicken/Nakorn-Pathom/Thailand/CU-K2/04(H5N1). Phylogenetic analyses of both genes revealed that all the eight avian isolates were closely related to the A/Chicken/Nakorn-Pathom/Thailand/CU-K2/ 04(H5N1). The amino acid sequence of the HA cleavage site revealed a common characteristic of a highly pathogenic virus strain. Moreover, a deletion of 20 amino acids in the NA stalk region was detected in all Thai isolates in contrast to the H5N1 strain that had caused outbreaks in eastern Asia in 1996-1997 and 2000-2001.
对2003年至2004年从泰国各种禽类中分离出的8株甲型流感病毒（H5N1）的血凝素（HA）基因和神经氨酸酶（NA）基因进行了鉴定，并与泰国分离株A/Chicken/Nakorn-Pathom/Thailand/CU-K2/04（H5N1）进行了比较。对这两个基因的系统发育分析表明，所有8株禽类分离株均与A/Chicken/Nakorn-Pathom/Thailand/CU-K2/04（H5N1）密切相关。HA裂解位点的氨基酸序列显示出高致病性病毒株的共同特征。此外，与1996 - 1997年和2000 - 2001年在东亚爆发疫情的H5N1毒株相比，在所有泰国分离株中均检测到NA茎区有20个氨基酸的缺失。
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