Gauri Andre J, Davis Andrew, Hong Thomas, Burke Martin C, Knight Bradley P
Division of Cardiology, Department of Internal Medicine, University of Chicago, Chicago, Ill, USA.
Am J Med. 2006 Feb;119(2):167.e17-21. doi: 10.1016/j.amjmed.2005.08.021.
This study determines whether there are racial or gender disparities in the use of implantable cardioverter-defibrillator therapy for primary prevention of sudden cardiac death.
Primary prevention of sudden death with implantable cardioverter-defibrillator therapy has been shown to improve survival for high-risk patients with coronary artery disease and left ventricular dysfunction.
The Center for Medicare and Medicaid Services Medicare database from the year 2002 was used to identify patients who were potential candidates for implantable cardioverter-defibrillator therapy on the basis of a combination of International Classification of Diseases, Ninth Revision, Clinical Modification codes that reflected the presence of an ischemic cardiomyopathy. This cohort was analyzed to determine which patients received implantable cardioverter-defibrillator therapy during the same year. The clinical characteristics of the potential implantable cardioverter-defibrillator candidates were compared with those who actually received an implantable cardioverter-defibrillator.
A total 132565 Medicare patients hospitalized during 2002 were identified as having an ischemic cardiomyopathy; 10370 (8%) of these patients underwent implantable cardioverter-defibrillator implantation during the same year. The percentage of patients who underwent implantable cardioverter-defibrillator implantation was higher for men compared with women (10.2% vs 3.5%; P<.001) and whites compared with blacks (8.1 vs 5.4; P<.001). After multivariate analysis, age, gender, and race remained independent predictors of implantable cardioverter-defibrillator implantation. Women with an ischemic cardiomyopathy were 65% less likely to receive implantable cardioverter-defibrillator therapy compared with men (P<.001), and black patients were 31% less likely to receive implantable cardioverter-defibrillator therapy compared with patients of other races (P < .001).
Use of implantable cardioverter-defibrillator therapy for primary prevention of sudden death among the elderly population identified as having an ischemic cardiomyopathy was significantly lower among women compared with men, and among blacks compared with whites. Further exploration of gender and racial barriers to appropriate implantable cardioverter-defibrillator use for primary prevention is needed.
本研究旨在确定在使用植入式心脏复律除颤器(ICD)治疗进行心脏性猝死一级预防方面是否存在种族或性别差异。
已证明使用ICD治疗进行猝死一级预防可提高患有冠状动脉疾病和左心室功能障碍的高危患者的生存率。
利用2002年医疗保险和医疗补助服务中心(CMS)的医疗保险数据库,根据反映缺血性心肌病存在的国际疾病分类第九版临床修订版(ICD-9-CM)代码组合,确定可能适合ICD治疗的患者。对该队列进行分析,以确定哪些患者在同一年接受了ICD治疗。将潜在ICD候选者的临床特征与实际接受ICD治疗的患者进行比较。
2002年住院的132565名医疗保险患者被确定患有缺血性心肌病;其中10370名(8%)患者在同一年接受了ICD植入。接受ICD植入的男性患者百分比高于女性(10.2%对3.5%;P<0.001),白人患者高于黑人患者(8.1对5.4;P<0.001)。多变量分析后,年龄、性别和种族仍然是ICD植入的独立预测因素。与男性相比,患有缺血性心肌病的女性接受ICD治疗的可能性低65%(P<0.001),与其他种族患者相比,黑人患者接受ICD治疗的可能性低31%(P<0.001)。
在被确定患有缺血性心肌病的老年人群中,使用ICD治疗进行猝死一级预防的比例,女性显著低于男性,黑人显著低于白人。需要进一步探讨在适当使用ICD进行一级预防方面存在的性别和种族障碍。