Two novel furan derivatives from Phellinus linteus with anti-complement activity.
作者信息
Min Byung-Sun, Yun Bong-Sik, Lee Hyeong-Kyu, Jung Hee-Jin, Jung Hyun-Ah, Choi Jae-Sue
机构信息
College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2006 Jun 15;16(12):3255-7. doi: 10.1016/j.bmcl.2006.03.027. Epub 2006 Apr 11.
PMID:16581246
Abstract
Two novel stereoisomers of furan derivatives, phellinusfurans A (1) and B (2), were isolated from the fruiting body of Phellinus linteus. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 exhibited significant anti-complement activity with IC50 values of 33.6 and 33.7 microM, respectively, in inhibiting the hemolytic activity of human serum against erythrocytes.
摘要
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