运动训练使大鼠比目鱼肌和腓肠肌的小动脉密度产生不均匀增加。
Exercise training produces nonuniform increases in arteriolar density of rat soleus and gastrocnemius muscle.
作者信息
Laughlin M Harold, Cook John Dylan, Tremble Rebecca, Ingram David, Colleran Patrick N, Turk James R
机构信息
Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211, USA.
出版信息
Microcirculation. 2006 Apr-May;13(3):175-86. doi: 10.1080/10739680600556829.
OBJECTIVE
Exercise training has been shown to increase regional blood flow capacity to muscle tissue containing fibers that experience increased activity during exercise. The purpose of this study was to test the hypothesis that the increased blood flow capacity is partially the result of increases in arteriolar density (number of arterioles/mm2 of tissue), specifically in skeletal muscle tissue, with the largest relative increase in muscle fiber activity during training bouts.
METHODS
This hypothesis was tested by comparing and contrasting the effects of endurance exercise training (ET) and interval sprint training (IST) on arteriolar density in soleus muscle (S) red (Gr) and white (Gw) portions of gastrocnemius muscle of male Sprague Dawley rats. ET rats completed 10 weeks of treadmill training 30 m/min, 15% grade, 60 min/day, 5 days/week, while IST rats completed 10 weeks of IST consisting of six 2.5-min exercise bouts, with 4.5-min rest between bouts (60 m/min, 15% incline), 5 days/week. The hypothesis would be supported if ET increased arteriolar density in S and Gr and if IST increased arteriolar density in Gw.
RESULTS
ET increased arteriolar density above values of sedentary rats (SED) in both the Gw (ET = 0.93 +/- 0.19 arterioles/microm2; SED = 0.44 +/- 0.09 arterioles/microm2) and Gr (ET = 0.97 +/- 0.1 arterioles/microm2; SED = 0.51 +/- 0.06 arterioles/microm2) muscles, but not in S (ET = 1.69 +/- 0.45 arterioles/microm2; SED = 1.51 +/- 0.34 arterioles/microm2) muscle. In contrast, IST did not alter arteriolar density in Gw or Gr muscle tissue. Although arterial wall thickness was greater in S (3.95 +/- 0.40 microm) and Gr (6.24 +/- 0.59 microm) than Gw (2.76 +/- 0.18 microm), neither ET or IST altered mean wall thickness in either muscle.
CONCLUSION
Increases in blood flow capacity produced in Gr and Gw by ET appear to be due in part to increased arteriolar density. In contrast, increased arteriolar density does not contribute to increased blood flow capacity of Gw in IST rats.
目的
运动训练已被证明可增加向含有在运动中活动增加的纤维的肌肉组织的局部血流能力。本研究的目的是检验以下假设：血流能力的增加部分是由于小动脉密度增加（每平方毫米组织中的小动脉数量），特别是在骨骼肌组织中，在训练期间肌肉纤维活动的相对增加最大。
方法
通过比较和对比耐力运动训练（ET）和间歇冲刺训练（IST）对雄性斯普拉格-道利大鼠比目鱼肌（S）、腓肠肌红色部分（Gr）和白色部分（Gw）小动脉密度的影响来检验该假设。ET组大鼠以30米/分钟、15%坡度、每天60分钟、每周5天的速度完成10周的跑步机训练，而IST组大鼠完成10周的IST训练，包括六次2.5分钟的运动回合，回合间休息4.5分钟（60米/分钟、15%坡度），每周5天。如果ET增加S和Gr中的小动脉密度，并且如果IST增加Gw中的小动脉密度，则该假设将得到支持。
结果
ET使Gw（ET = 0.93±0.19条小动脉/平方微米；SED = 0.44±0.09条小动脉/平方微米）和Gr（ET = 0.97±0.1条小动脉/平方微米；SED = 0.51±0.06条小动脉/平方微米）肌肉中的小动脉密度高于久坐不动的大鼠（SED），但在S（ET = 1.69±0.45条小动脉/平方微米；SED = 1.51±0.34条小动脉/平方微米）肌肉中未增加。相比之下，IST并未改变Gw或Gr肌肉组织中的小动脉密度。尽管S（3.95±0.
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