一氧化氮在肿瘤进展中的作用。

The role of nitric oxide in tumour progression.

作者信息

Fukumura Dai, Kashiwagi Satoshi, Jain Rakesh K

机构信息

Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

出版信息

Nat Rev Cancer. 2006 Jul;6(7):521-34. doi: 10.1038/nrc1910.

DOI:10.1038/nrc1910

PMID:16794635

Abstract

Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are known to exert both pro- and anti-tumour effects. We summarize our current understanding of the role of NO in tumour progression, especially in relation to angiogenesis and vascular functions. We also discuss potential strategies for cancer treatment that modulate NO production and/or its downstream signalling pathways.

摘要

一氧化氮（NO）和一氧化氮合酶在恶性肿瘤中普遍存在，已知它们具有促肿瘤和抗肿瘤两种作用。我们总结了目前对NO在肿瘤进展中的作用的理解，特别是与血管生成和血管功能相关的作用。我们还讨论了调节NO产生和/或其下游信号通路的癌症治疗潜在策略。