蛇床子素治疗动物高脂血症和酒精性脂肪肝的实验研究
Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals.
作者信息
Song Fang, Xie Mei-Lin, Zhu Lu-Jia, Zhang Ke-Ping, Xue Jie, Gu Zhen-Lun
机构信息
Department of Pharmacology, Medical School of Soochow University, Suzhou 215123, Jiangsu Province, China.
出版信息
World J Gastroenterol. 2006 Jul 21;12(27):4359-63. doi: 10.3748/wjg.v12.i27.4359.
AIM
To evaluate the effects of osthole on fatty liver, and investigate the possible mechanism.
METHODS
A quail model with hyperlipidemic fatty liver and rat model with alcoholic fatty liver were set up by feeding high fat diet and alcohol, respectively. These experimental animals were then treated with osthole 5-20 mg/kg for 6 wk, respectively. Whereafter, the lipid in serum and hepatic tissue, and coefficient of hepatic weight were measured.
RESULTS
After treatment with osthole the levels of serum total cholesterol (TC), triglyceride (TG), lower density lipoprotein-cholesterol (LDL-C), coefficient of hepatic weight, and the hepatic tissue contents of TC and TG were significantly decreased. The activity of superoxide dismutase (SOD) in liver was improved. In alcohol-induced fatty liver rats, the level of malondialdehyde (MDA) in liver was decreased. In high fat-induced fatty liver quails, glutathione peroxidase (GSH-PX) in liver was significantly improved. The histological evaluation of liver specimens demonstrated that the osthole dramatically decreased lipid accumulation.
CONCLUSION
These results suggested that osthole had therapeutic effects on both alcohol and high fat-induced fatty liver. The mechanism might be associated with its antioxidation.
目的
评估蛇床子素对脂肪肝的影响，并探讨其可能的作用机制。
方法
分别通过高脂饮食和酒精喂养建立高脂血症脂肪肝鹌鹑模型和酒精性脂肪肝大鼠模型。然后分别用5 - 20mg/kg蛇床子素对这些实验动物进行6周治疗。之后，测定血清和肝组织中的脂质以及肝重系数。
结果
蛇床子素治疗后，血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL - C）水平、肝重系数以及肝组织中TC和TG含量均显著降低。肝脏中超氧化物歧化酶（SOD）活性得到改善。在酒精性脂肪肝大鼠中，肝脏中丙二醛（MDA）水平降低。在高脂性脂肪肝鹌鹑中，肝脏中谷胱甘肽过氧化物酶（GSH - PX）显著改善。肝脏标本的组织学评估表明，蛇床子素显著降低了脂质蓄积。
结论
这些结果表明，蛇床子素对酒精性和高脂性脂肪肝均有治疗作用。其机制可能与其抗氧化作用有关。
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