远志中新的酰化三萜皂苷

New acylated triterpene saponins from Polygala tenuifolia willd.

作者信息

Li J, Jiang Y, Tu P-F

机构信息

Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China.

出版信息

J Asian Nat Prod Res. 2006 Sep;8(6):499-503. doi: 10.1080/10286020500173358.

DOI:10.1080/10286020500173358

PMID:16931424

Abstract

Two new acylated presenegenin glycosides E-onjisaponin H (5) and Z-onjisaponin (6) together with seven known saponins were isolated from the roots of Polygala tenuifolia Willd. Compounds 5 and 6 were obtained as a pair of isomers due to trans and cis-p-methoxycinnamoyl. Their structures were elucidated mainly by 2D-NMR techniques including 1H-1HCOSY, TOCSY, HSQC, HMBC as 3-O-(beta-D-glucopyranosyl) presenegenin 28-[O-beta-D-apiofuranosyl-(1 --> 3)-O-[beta-D-xylopyranosyl-(1 --> 4)]-O-alpha-L-rhamnopyranosyl-(1 --> 2)-O-[alpha-L-rhamnopyranosyl-(1 --> 3)]-4-O-[(E)-p-methoxycinnamoyl]-beta-D-fucopyranosyl] ester (5) and its (Z)-isomer (6).

摘要

从远志的根中分离得到两种新的酰化前人参皂苷元糖苷E-远志皂苷H（5）和Z-远志皂苷（6）以及七种已知的皂苷。化合物5和6是由于反式和顺式对甲氧基肉桂酰基而得到的一对异构体。它们的结构主要通过二维核磁共振技术包括1H-1HCOSY、TOCSY、HSQC、HMBC确定为3-O-（β-D-吡喃葡萄糖基）前人参皂苷元28-[O-β-D-阿吡喃糖基-（1→3）-O-[β-D-吡喃木糖基-（1→4）]-O-α-L-吡喃鼠李糖基-（1→2）-O-[α-L-吡喃鼠李糖基-（1→3）]-4-O-[(E)-对甲氧基肉桂酰基]-β-D-吡喃岩藻糖基]酯（5）及其（Z）-异构体（6）。