癌症治疗中的端粒酶抑制：基于分子的方法。
Telomerase inhibition in cancer therapeutics: molecular-based approaches.
作者信息
Cunningham A P, Love W K, Zhang R W, Andrews L G, Tollefsbol T O
机构信息
Department of Biology, University of Alabama at Birmingham, AL 35294, USA.
出版信息
Curr Med Chem. 2006;13(24):2875-88. doi: 10.2174/092986706778521887.
Abstract
Current standard cancer therapies (chemotherapy and radiation) often cause serious adverse off-target effects. Drug design strategies are therefore being developed that will more precisely target cancer cells for destruction while leaving surrounding normal cells relatively unaffected. Telomerase, widely expressed in most human cancers but almost undetectable in normal somatic cells, provides an exciting drug target. This review focuses on recent pharmacogenomic approaches to telomerase inhibition. Antisense oligonucleotides, RNA interference, ribozymes, mutant expression, and the exploitation of differential telomerase expression as a strategy for targeted oncolysis are discussed here in the context of cancer therapeutics. Reports of synergism between telomerase inhibitors and traditional cancer therapeutic agents are also analyzed.
摘要
当前的标准癌症疗法（化疗和放疗）常常会引发严重的非靶向性不良副作用。因此，正在研发一些药物设计策略，以便能更精准地靶向癌细胞进行破坏，同时使周围的正常细胞相对不受影响。端粒酶在大多数人类癌症中广泛表达，但在正常体细胞中几乎检测不到，它是一个令人兴奋的药物靶点。本综述聚焦于近期用于抑制端粒酶的药物基因组学方法。本文在癌症治疗的背景下讨论了反义寡核苷酸、RNA干扰、核酶、突变体表达以及利用端粒酶的差异表达作为靶向溶瘤策略。还分析了端粒酶抑制剂与传统癌症治疗药物之间协同作用的相关报道。
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