突触发育过程中的可塑性与第二信使
Plasticity and second messengers during synapse development.
作者信息
Griffith Leslie C, Budnik Vivian
机构信息
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA.
出版信息
Int Rev Neurobiol. 2006;75:237-65. doi: 10.1016/S0074-7742(06)75011-5.
Abstract
Effective function of the locomotor system in the larva requires a continuous adjustment of synaptic architecture and neurotransmission at the neuromuscular junction (NMJ). This feature has made the larval NMJ a favorite model to study the genetic and molecular mechanisms underlying synapse plasticity. This chapter will review experimental strategies used to study plasticity at the NMJ, the cellular parameters affected during plastic changes, and many of the known molecules involved in plastic changes. In addition, signal transduction pathways activated during plasticity will be discussed.
摘要
幼虫运动系统的有效功能需要神经肌肉接头（NMJ）处突触结构和神经传递的持续调节。这一特性使幼虫NMJ成为研究突触可塑性潜在遗传和分子机制的理想模型。本章将综述用于研究NMJ可塑性的实验策略、可塑性变化过程中受影响的细胞参数，以及许多参与可塑性变化的已知分子。此外，还将讨论可塑性过程中激活的信号转导途径。
相似文献
1
Plasticity and second messengers during synapse development.
Int Rev Neurobiol. 2006;75:237-65. doi: 10.1016/S0074-7742(06)75011-5.
2
Second messenger systems underlying plasticity at the neuromuscular junction.
Int Rev Neurobiol. 1999;43:119-38. doi: 10.1016/s0074-7742(08)60543-7.
3
Drosophila larval neuromuscular junction: molecular components and mechanisms underlying synaptic plasticity.
Microsc Res Tech. 2000 Apr 1;49(1):14-25. doi: 10.1002/(SICI)1097-0029(20000401)49:1<14::AID-JEMT3>3.0.CO;2-G.
4
Synapse maturation and structural plasticity at Drosophila neuromuscular junctions.
Curr Opin Neurobiol. 1996 Dec;6(6):858-67. doi: 10.1016/s0959-4388(96)80038-9.
5
Glutamate receptors at the Drosophila neuromuscular junction.
Int Rev Neurobiol. 2006;75:165-79. doi: 10.1016/S0074-7742(06)75008-5.
6
Synaptic plasticity: keeping synapses under control.
Curr Biol. 1998;8(16):R564-7. doi: 10.1016/s0960-9822(07)00362-4.
7
Introduction on the use of the Drosophila embryonic/larval neuromuscular junction as a model system to study synapse development and function, and a brief summary of pathfinding and target recognition.
Int Rev Neurobiol. 2006;75:1-31. doi: 10.1016/S0074-7742(06)75001-2.
8
latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity.
Neuron. 1999 May;23(1):55-70. doi: 10.1016/s0896-6273(00)80753-9.
9
Synaptic plasticity: fastening synapses by adhesion.
Curr Biol. 1997 Jan 1;7(1):R28-30. doi: 10.1016/s0960-9822(06)00013-3.
10
Activity-dependent regulation of transcription during development of synapses.
Int Rev Neurobiol. 2006;75:287-305. doi: 10.1016/S0074-7742(06)75013-9.
引用本文的文献
1
Patronin regulates presynaptic microtubule organization and neuromuscular junction development in .
iScience. 2024 Jan 18;27(2):108944. doi: 10.1016/j.isci.2024.108944. eCollection 2024 Feb 16.
2
In Vivo cAMP Dynamics in Drosophila Larval Neurons.
Methods Mol Biol. 2022;2483:181-194. doi: 10.1007/978-1-0716-2245-2_11.
3
Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination.
Elife. 2020 Sep 30;9:e56738. doi: 10.7554/eLife.56738.
4
Two Pathways for the Activity-Dependent Growth and Differentiation of Synaptic Boutons in .
eNeuro. 2019 Aug 22;6(4). doi: 10.1523/ENEURO.0060-19.2019. Print 2019 Jul/Aug.
5
Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila.
Neuron. 2017 Aug 2;95(3):623-638.e4. doi: 10.1016/j.neuron.2017.06.034. Epub 2017 Jul 14.
6
cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons.
Cell Rep. 2016 Oct 25;17(5):1238-1246. doi: 10.1016/j.celrep.2016.09.090.
7
Development and plasticity of the Drosophila larval neuromuscular junction.
Wiley Interdiscip Rev Dev Biol. 2013 Sep-Oct;2(5):647-70. doi: 10.1002/wdev.108. Epub 2013 Feb 5.
8
Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst.
EMBO J. 2013 Jul 17;32(14):2039-55. doi: 10.1038/emboj.2013.147. Epub 2013 Jun 28.
9
Rapid feedback regulation of synaptic efficacy during high-frequency activity at the Drosophila larval neuromuscular junction.
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9142-7. doi: 10.1073/pnas.1221314110. Epub 2013 May 14.
10
Lola regulates glutamate receptor expression at the Drosophila neuromuscular junction.
Biol Open. 2012 Apr 15;1(4):362-75. doi: 10.1242/bio.2012448. Epub 2012 Feb 16.
本文引用的文献
1
Postsynaptic mad signaling at the Drosophila neuromuscular junction.
Curr Biol. 2006 Apr 4;16(7):625-35. doi: 10.1016/j.cub.2006.02.061.
2
The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development.
Neuron. 2006 Feb 16;49(4):517-31. doi: 10.1016/j.neuron.2006.01.026.
3
Coordination and modulation of locomotion pattern generators in Drosophila larvae: effects of altered biogenic amine levels by the tyramine beta hydroxlyase mutation.
J Neurosci. 2006 Feb 1;26(5):1486-98. doi: 10.1523/JNEUROSCI.4749-05.2006.
4
Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2.
Science. 2005 Nov 25;310(5752):1344-7. doi: 10.1126/science.1117051.
5
Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth.
Science. 2005 Nov 4;310(5749):858-63. doi: 10.1126/science.1117541.
6
The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase.
Curr Biol. 2005 Oct 11;15(19):1701-11. doi: 10.1016/j.cub.2005.08.035.
7
Integrin structure, allostery, and bidirectional signaling.
Annu Rev Cell Dev Biol. 2005;21:381-410. doi: 10.1146/annurev.cellbio.21.090704.151217.
8
Disruption of insulin pathways alters trehalose level and abolishes sexual dimorphism in locomotor activity in Drosophila.
J Neurobiol. 2006 Jan;66(1):19-32. doi: 10.1002/neu.20193.
9
LIM Kinase1 controls synaptic stability downstream of the type II BMP receptor.
Neuron. 2005 Sep 1;47(5):695-708. doi: 10.1016/j.neuron.2005.08.010.
10
Heterogeneity in synaptic transmission along a Drosophila larval motor axon.
Nat Neurosci. 2005 Sep;8(9):1188-96. doi: 10.1038/nn1526. Epub 2005 Aug 14.
Zotero 插件