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利用成体干细胞的组织工程。

Tissue engineering using adult stem cells.

作者信息

Eberli Daniel, Atala Anthony

机构信息

Wake Forest Institute for Regenerative Medicine, Winston Salem, North Carolina, USA.

出版信息

Methods Enzymol. 2006;420:287-302. doi: 10.1016/S0076-6879(06)20013-2.

Abstract

Patients with a variety of diseases may be treated with transplanted tissues and organs. However, there is a shortage of donor tissues and organs, which is worsening yearly because of the aging population. Scientists in the field of tissue engineering are applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. The stem cell field is also advancing rapidly, opening new options for cellular therapy and tissue engineering. The use of adult stem cells for tissue engineering applications is promising. This chapter discusses applications of these new technologies for the engineering of tissues and organs. The first part provides an overview of regenerative medicine and tissue engineering techniques; the second highlights different adult stem cell populations used for tissue regeneration.

摘要

患有各种疾病的患者可以接受移植组织和器官的治疗。然而,供体组织和器官短缺,并且由于人口老龄化,这种短缺情况逐年恶化。组织工程领域的科学家们正在应用细胞移植、材料科学和生物工程的原理来构建生物替代品,以恢复和维持患病及受损组织的正常功能。干细胞领域也在迅速发展,为细胞治疗和组织工程开辟了新的选择。将成体干细胞用于组织工程应用很有前景。本章讨论这些新技术在组织和器官工程中的应用。第一部分概述了再生医学和组织工程技术;第二部分重点介绍了用于组织再生的不同成体干细胞群体。

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