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失眠的心理与行为治疗:近期证据更新(1998 - 2004年)

Psychological and behavioral treatment of insomnia:update of the recent evidence (1998-2004).

作者信息

Morin Charles M, Bootzin Richard R, Buysse Daniel J, Edinger Jack D, Espie Colin A, Lichstein Kenneth L

机构信息

Université Laval, Québec, Canada.

出版信息

Sleep. 2006 Nov;29(11):1398-414. doi: 10.1093/sleep/29.11.1398.

Abstract

BACKGROUND

Recognition that psychological and behavioral factors play an important role in insomnia has led to increased interest in therapies targeting these factors. A review paper published in 1999 summarized the evidence regarding the efficacy of psychological and behavioral treatments for persistent insomnia. The present review provides an update of the evidence published since the original paper. As with the original paper, this review was conducted by a task force commissioned by the American Academy of Sleep Medicine in order to update its practice parameters on psychological and behavioral therapies for insomnia.

METHODS

A systematic review was conducted on 37 treatment studies (N = 2246 subjects/patients) published between 1998 and 2004 inclusively and identified through Psyclnfo and Medline searches. Each study was systematically reviewed with a standard coding sheet and the following information was extracted: Study design, sample (number of participants, age, gender), diagnosis, type of treatments and controls, primary and secondary outcome measures, and main findings. Criteria for inclusion of a study were as follows: (a) the main sleep diagnosis was insomnia (primary or comorbid), (b) at least 1 treatment condition was psychological or behavioral in content, (c) the study design was a randomized controlled trial, a nonrandomized group design, a clinical case series or a single subject experimental design with a minimum of 10 subjects, and (d) the study included at least 1 of the following as dependent variables: sleep onset latency, number and/or duration of awakenings, total sleep time, sleep efficiency, or sleep quality.

RESULTS

Psychological and behavioral therapies produced reliable changes in several sleep parameters of individuals with either primary insomnia or insomnia associated with medical and psychiatric disorders. Nine studies documented the benefits of insomnia treatment in older adults or for facilitating discontinuation of medication among chronic hypnotic users. Sleep improvements achieved with treatment were well sustained over time; however, with the exception of reduced psychological symptoms/ distress, there was limited evidence that improved sleep led to clinically meaningful changes in other indices of morbidity (e.g., daytime fatigue). Five treatments met criteria for empirically-supported psychological treatments for insomnia: Stimulus control therapy, relaxation, paradoxical intention, sleep restriction, and cognitive-behavior therapy.

DISCUSSION

These updated findings provide additional evidence in support of the original review's conclusions as to the efficacy and generalizability of psychological and behavioral therapies for persistent insomnia. Nonetheless, further research is needed to develop therapies that would optimize outcomes and reduce morbidity, as would studies of treatment mechanisms, mediators, and moderators of outcomes. Effectiveness studies are also needed to validate those therapies when implemented in clinical settings (primary care), by non-sleep specialists. There is also a need to disseminate more effectively the available evidence in support of psychological and behavioral interventions to health-care practitioners working on the front line.

摘要

背景

认识到心理和行为因素在失眠中起着重要作用,这使得人们对针对这些因素的治疗方法越来越感兴趣。1999年发表的一篇综述论文总结了有关心理和行为治疗对持续性失眠疗效的证据。本综述提供了自原始论文发表以来所公布证据的最新情况。与原始论文一样,本综述由美国睡眠医学学会委托的一个特别工作组进行,目的是更新其关于失眠心理和行为疗法的实践参数。

方法

对1998年至2004年期间发表的37项治疗研究(N = 2246名受试者/患者)进行了系统综述,这些研究通过心理学文摘数据库(Psyclnfo)和医学期刊数据库(Medline)检索确定。每项研究都使用标准编码表进行系统综述,并提取以下信息:研究设计、样本(参与者数量、年龄、性别)、诊断、治疗和对照类型、主要和次要结局指标以及主要发现。纳入研究的标准如下:(a)主要睡眠诊断为失眠(原发性或共病性),(b)至少一种治疗条件在内容上是心理或行为方面的,(c)研究设计为随机对照试验、非随机分组设计、临床病例系列或至少有10名受试者的单病例实验设计,(d)研究至少包括以下作为因变量之一:入睡潜伏期、觉醒次数和/或持续时间、总睡眠时间、睡眠效率或睡眠质量。

结果

心理和行为疗法在原发性失眠患者或与医学和精神疾病相关的失眠患者的几个睡眠参数上产生了可靠的变化。九项研究记录了失眠治疗对老年人的益处或有助于慢性催眠药物使用者停药。治疗所取得的睡眠改善随着时间的推移得到了很好的维持;然而,除了心理症状/痛苦减轻外,几乎没有证据表明睡眠改善会导致其他发病率指标(如白天疲劳)出现具有临床意义的变化。五种治疗方法符合经实证支持的失眠心理治疗标准:刺激控制疗法、放松疗法、矛盾意向疗法、睡眠限制疗法和认知行为疗法。

讨论

这些更新后的发现为原始综述关于心理和行为疗法对持续性失眠的疗效和可推广性的结论提供了更多证据。尽管如此,仍需要进一步研究来开发能够优化治疗效果并降低发病率的疗法,以及对治疗机制、调节因素和结局调节因素进行研究。还需要进行有效性研究,以验证这些疗法在临床环境(初级保健)中由非睡眠专科医生实施时的效果。此外,还需要更有效地向一线医护人员传播支持心理和行为干预的现有证据。

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