解读导致胃癌发生的潜在遗传和表观遗传事件。

Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis.

作者信息

Vogiatzi Paraskevi, Vindigni Carla, Roviello Franco, Renieri Alessandra, Giordano Antonio

机构信息

Department of Molecular Biology, Medical Genetics, University of Siena, Siena, Italy.

出版信息

J Cell Physiol. 2007 May;211(2):287-95. doi: 10.1002/jcp.20982.

DOI:10.1002/jcp.20982

PMID:17238139

Abstract

Gastric cancer is a common aggressive malignancy. Although its incidence shows considerable variation among different countries, gastric cancer is still a major health problem worldwide. The causes of stomach cancer are not completely understood. What is clear is that gastric cancer is a multi-stage process involving genetic and epigenetic factors. This review is an in-depth study of the known genetic and epigenetic processes in the development of this tumor, and delineates possible approaches in gene and epigenetic therapy.

摘要

胃癌是一种常见的侵袭性恶性肿瘤。尽管其发病率在不同国家间存在显著差异，但胃癌仍是全球范围内的一个主要健康问题。胃癌的病因尚未完全明确。清楚的是，胃癌是一个涉及遗传和表观遗传因素的多阶段过程。本综述深入研究了该肿瘤发生过程中已知的遗传和表观遗传过程，并阐述了基因和表观遗传治疗的可能方法。