大阪大学老年双胞胎登记处：表观遗传学与患衰老相关疾病的同卵双胞胎不一致情况

The Osaka University Aged Twin Registry: epigenetics and identical twins discordant for aging-dependent diseases.

作者信息

Hayakawa Kazuo, Kato Kenji, Onoi Miyuki, Yang-Ping Cai, Kanamori Masao, Doi Syuichi, Hayashi Chisato, Kikuchi Hiroyuki, Nishihara Reiko, Kadota Kensuke

机构信息

Department of Health Promotion Science, Faculty of Medicine, Osaka University, 1-7 Yamadaoka, Suita City, Osaka-fu, Japan.

出版信息

Twin Res Hum Genet. 2006 Dec;9(6):808-10. doi: 10.1375/183242706779462471.

DOI:10.1375/183242706779462471

PMID:17254413

Abstract

The Osaka University Aged Twin Registry (OUATR) is the largest adult twin registry in Japan. Since its establishment in 1974, the OUATR has conducted a number of studies with particular focus on the environmental contribution to physical-cognitive-mental aging, longevity and aging-dependent diseases in later adulthood. The registry consists of 12,000 pairs of Japanese twins born between 1900 and 1935. Two hundred and fifty pairs of twins have undergone comprehensive medical examination to date. Follow-up questionnaires have been mailed out on a regular basis, for the purpose of checking current vital statuses, health conditions, and so forth. The main objective of this longitudinal twin study is to contribute to the prevention of lifestyle-related diseases and the promotion of successful aging.

摘要

大阪大学老年双胞胎登记处（OUATR）是日本最大的成年双胞胎登记处。自1974年成立以来，OUATR开展了多项研究，特别关注环境因素对成年后期身体-认知-心理衰老、长寿及衰老相关疾病的影响。该登记处包含12000对出生于1900年至1935年的日本双胞胎。迄今为止，已有250对双胞胎接受了全面的医学检查。定期邮寄随访调查问卷，以核查目前的生命状态、健康状况等。这项纵向双胞胎研究的主要目的是促进与生活方式相关疾病的预防及成功老龄化。