线粒体与神经退行性变

Mitochondria and neurodegeneration.

作者信息

Petrozzi Lucia, Ricci Giulia, Giglioli Noemi J, Siciliano Gabriele, Mancuso Michelangelo

机构信息

Department of Neuroscience, University of Pisa, Via Roma 67, Pisa, 56126, Italy.

出版信息

Biosci Rep. 2007 Jun;27(1-3):87-104. doi: 10.1007/s10540-007-9038-z.

DOI:10.1007/s10540-007-9038-z

PMID:17486441

Abstract

Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question "is mitochondrial dysfunction a necessary step in neurodegeneration?" is still unanswered. In this review, we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis and Huntington's disease) and discuss the role of the mitochondria in the pathogenetic cascade leading to neurodegeneration.

摘要

许多证据表明，线粒体在与衰老相关的神经退行性疾病中起着核心作用。然而，尽管在神经退行性疾病患者的各种组织中线粒体存在形态、生化和分子异常的证据，但“线粒体功能障碍是神经退行性变的必要步骤吗？”这个问题仍然没有答案。在这篇综述中，我们重点介绍了一些主要的神经退行性疾病（阿尔茨海默病、帕金森病、肌萎缩侧索硬化症和亨廷顿舞蹈病），并讨论了线粒体在导致神经退行性变的发病级联反应中的作用。