间隙连接在左右模式形成中提供了新的联系。

Gap junctions provide new links in left-right patterning.

作者信息

Oviedo Néstor J, Levin Michael

机构信息

The Forsyth Center for Regenerative and Developmental Biology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA.

出版信息

Cell. 2007 May 18;129(4):645-7. doi: 10.1016/j.cell.2007.05.005.

DOI:10.1016/j.cell.2007.05.005

PMID:17512395

Abstract

Gap junctions are increasingly recognized as key regulators of embryonic development, nervous system function, and neoplasia. Chuang et al. (2007) now show that developing neural circuits use communication through gap junctions to establish left-right asymmetry in the central nervous system of the worm Caenorhabditis elegans, revealing that nematodes share a mechanism for left-right asymmetry in common with vertebrates.

摘要

间隙连接越来越被认为是胚胎发育、神经系统功能和肿瘤形成的关键调节因子。Chuang等人（2007年）现在表明，发育中的神经回路通过间隙连接进行通讯，以在秀丽隐杆线虫的中枢神经系统中建立左右不对称性，这揭示了线虫与脊椎动物具有共同的左右不对称机制。