肽合成中“困难序列”偶联效率提高的最新进展。

Recent progress in the improvement of the coupling efficiency of "difficult sequences" in peptide synthesis.

作者信息

Han Xiang, Wang De-xin

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

出版信息

Yao Xue Xue Bao. 2007 Feb;42(2):111-7.

PMID:17518036

Abstract

Even though chemistry is now in place that potentially allows high coupling efficiencies to be attained, successful coupling is usually a challenge when so-called "difficult sequences" is encountered in peptide synthesis. Some factors that affect the coupling efficiency have been discussed and related methods to overcome those obstacles have been introduced in present review. All suggestions proposed here are valuable and also feasible to improve the coupling completeness in both liquid-phase or solid-phase

摘要

尽管目前已具备可能实现高偶联效率的化学方法，但在肽合成中遇到所谓“困难序列”时，成功偶联通常仍是一项挑战。本综述讨论了一些影响偶联效率的因素，并介绍了克服这些障碍的相关方法。这里提出的所有建议对于提高液相或固相中偶联的完全性都是有价值且可行的。