神经营养因子与精神分裂症

Neurotrophins and schizophrenia.

作者信息

Buckley Peter F, Mahadik Sahebarao, Pillai Anilkumar, Terry Alvin

机构信息

Department of Psychiatry and Health Behavior, Medical College of Georgia, 1515 Pope Avenue, Augusta, Georgia 30912, United States.

出版信息

Schizophr Res. 2007 Aug;94(1-3):1-11. doi: 10.1016/j.schres.2007.01.025. Epub 2007 May 23.

DOI:10.1016/j.schres.2007.01.025

PMID:17524622

Abstract

Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia--as well as the propensity for progressive brain changes--there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.

摘要

神经营养因子在神经元发育、突触形成以及对应激/焦虑刺激的反应中发挥着既定作用。此外，这些因子还是单胺能、γ-氨基丁酸能和胆碱能系统的神经调节剂。随着对精神分裂症发育神经生物学以及大脑进行性变化倾向的认识不断加深，有关精神分裂症中神经营养因子表达异常的新信息不断涌现。本文综述了关于神经营养因子与精神分裂症的文献。并提供了一个理解精神分裂症复发神经生物学的框架。