坦桑尼亚HIV感染患者中Toll样受体4 Asp299Gly变异与结核病易感性
The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients in Tanzania.
作者信息
Ferwerda Bart, Kibiki Gibson S, Netea Mihai G, Dolmans Wil M V, van der Ven Andre J
机构信息
Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
出版信息
AIDS. 2007 Jun 19;21(10):1375-7. doi: 10.1097/QAD.0b013e32814e6b2d.
Toll-like receptor 4 (TLR4) plays an important role in the pattern recognition of Mycobacterium tuberculosis, and polymorphisms in the TLR4 gene influence the function of the receptor. We therefore investigated in a cohort of HIV-infected Tanzanian patients whether the Asp299Gly TLR4 polymorphism is associated with the development of active tuberculosis. We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell counts in patients with the Asp299Gly TLR4 polymorphism.
Toll样受体4（TLR4）在结核分枝杆菌的模式识别中起重要作用，TLR4基因的多态性会影响该受体的功能。因此，我们在一群感染了HIV的坦桑尼亚患者中进行了研究，以探讨TLR4基因Asp299Gly多态性是否与活动性结核病的发生有关。我们发现，具有TLR4基因Asp299Gly多态性的患者发生活动性结核病的风险更高，且CD4 T细胞计数减少。
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