[细胞黏附分子在突触活动调节中的作用]
[Role of cell adhesion molecules in the modulation of synaptic activity].
作者信息
Nikonenko O H, Skybo H H
出版信息
Fiziol Zh (1994). 2007;53(2):70-7.
PMID:17595915
Abstract
Cell adhesion molecules (CAMs) can influence various developmental events, including cell migration, proliferation, and differentiation. Recent advances have provided evidence that in addition to their adhesive properties, CAMs can affect intracellular signalling and synaptic function. This review focuses on the role of CAMs in the modulation of synaptic activity. Some mechanisms are being discussed including one that involve the ability of CAMs to initiate the formation of scaffolds permitting efficient signalling.
摘要
细胞黏附分子（CAMs）可影响多种发育事件，包括细胞迁移、增殖和分化。最近的研究进展表明，除了其黏附特性外，细胞黏附分子还可影响细胞内信号传导和突触功能。本综述重点关注细胞黏附分子在调节突触活动中的作用。文中讨论了一些机制，包括一种涉及细胞黏附分子启动支架形成以实现高效信号传导的能力的机制。
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