灼口综合征患者的血清白细胞介素-6及其与抑郁和疼痛感知的关系。
Serum interleukin-6 in patients with burning mouth syndrome and relationship with depression and perceived pain.
作者信息
Chen Qianming, Xia Juan, Lin Mei, Zhou Hongmei, Li Bingqi
机构信息
Department of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
出版信息
Mediators Inflamm. 2007;2007:45327. doi: 10.1155/2007/45327.
OBJECTIVE
To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients.
METHODS
48 BMS patients and 31 healthy controls participated in the study. Serum interleukin-6 was measured by means of ELISA. Hamilton rating scale of depression (HRSD) and visual analogue scale (VAS) were used to quantitate depressive status and pain levels of subjects, respectively.
RESULTS
15 (31%) patients displayed substantial depressive symptoms (HRSD > or = 16). HRSD scores of patients were significantly higher than controls and positively correlated to their VAS values (P = .002). Serum interleukin-6 in patients was much lower than controls and negatively correlated to their VAS values (P = .011). However, no significant relations were found between interleukin-6 and HRSD scores (P = .317).
CONCLUSIONS
Serum interleukin-6 in patients with burning mouth syndrome is decreased and negatively correlated to chronic pain. Both psychological and neuropathic disorders might act as precipitating factors in BMS etiopathogenesis.
目的
研究灼口综合征（BMS）患者血清白细胞介素-6的变化及其临床意义。
方法
48例BMS患者和31名健康对照者参与本研究。采用酶联免疫吸附测定法（ELISA）检测血清白细胞介素-6。分别使用汉密尔顿抑郁量表（HRSD）和视觉模拟评分法（VAS）对受试者的抑郁状态和疼痛程度进行量化。
结果
15例（31%）患者表现出明显的抑郁症状（HRSD≥16）。患者的HRSD评分显著高于对照组，且与VAS值呈正相关（P = 0.002）。患者血清白细胞介素-6水平明显低于对照组，且与VAS值呈负相关（P = 0.011）。然而，白细胞介素-6与HRSD评分之间未发现显著相关性（P = 0.317）。
结论
灼口综合征患者血清白细胞介素-6水平降低，且与慢性疼痛呈负相关。心理和神经病变可能是BMS发病机制中的诱发因素。
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