金属蛋白酶在血小板功能中的作用。

Role of metalloproteinases in platelet function.

作者信息

Santos-Martínez María José, Medina Carlos, Jurasz Paul, Radomski Marek W

机构信息

School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin, Ireland.

出版信息

Thromb Res. 2008;121(4):535-42. doi: 10.1016/j.thromres.2007.06.002. Epub 2007 Aug 2.

DOI:10.1016/j.thromres.2007.06.002

PMID:17681591

Abstract

Platelets contain and release matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and disintegrin metalloproteinases (ADAMs) including MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP (MMP-14), ADAM-10, ADAM-17, ADAMTS-13, TIMP-1, TIMP-2 and TIMP-4. These proteins exert several effects regulating platelet functions such as agonist-stimulated platelet adhesion and aggregation, tumour cell-induced platelet aggregation and platelet-leukocyte aggregation. In this review, mechanisms of MMPs, TIMPs and ADAMs on platelets are discussed.

摘要

血小板含有并释放基质金属蛋白酶（MMPs）、其抑制剂（TIMPs）和整合素金属蛋白酶（ADAMs），包括MMP-1、MMP-2、MMP-3、MMP-9、MT1-MMP（MMP-14）、ADAM-10、ADAM-17、ADAMTS-13、TIMP-1、TIMP-2和TIMP-4。这些蛋白质发挥多种作用来调节血小板功能，如激动剂刺激的血小板黏附和聚集、肿瘤细胞诱导的血小板聚集以及血小板-白细胞聚集。在这篇综述中，将讨论MMPs、TIMPs和ADAMs对血小板作用的机制。