Toll样受体及Toll样受体遗传学在人类疾病中的作用。

The effect of toll-like receptors and toll-like receptor genetics in human disease.

作者信息

Garantziotis Stavros, Hollingsworth John W, Zaas Aimee K, Schwartz David A

机构信息

Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

出版信息

Annu Rev Med. 2008;59:343-59. doi: 10.1146/annurev.med.59.061206.112455.

DOI:10.1146/annurev.med.59.061206.112455

PMID:17845139

Abstract

Toll-like receptors (TLRs) enable innate immune recognition of endogenous and exogenous prototypic ligands. They also orchestrate innate and adaptive immune response to infection, inflammation, and tissue injury. Given their significance in the immune response, it is not surprising that genetic variations of TLRs can affect their function and by extension affect the response of the organism to environmental stimuli. The genetics of TLRs provides important insights in gene-environment interactions in health and disease, and it may enable scientists to assess patients' susceptibility to diseases or predict their response to treatments.

摘要

Toll样受体（TLRs）能够对内源性和外源性原型配体进行先天性免疫识别。它们还协调针对感染、炎症和组织损伤的先天性和适应性免疫反应。鉴于它们在免疫反应中的重要性，TLRs的基因变异会影响其功能，进而影响机体对环境刺激的反应也就不足为奇了。TLRs的遗传学为健康和疾病中的基因-环境相互作用提供了重要见解，并且可能使科学家能够评估患者对疾病的易感性或预测他们对治疗的反应。