叉头框（Fox）蛋白在癌症中的新作用。

The emerging roles of forkhead box (Fox) proteins in cancer.

作者信息

Myatt Stephen S, Lam Eric W-F

机构信息

Cancer Research UK laboratories, Department of Oncology, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

出版信息

Nat Rev Cancer. 2007 Nov;7(11):847-59. doi: 10.1038/nrc2223.

DOI:10.1038/nrc2223

PMID:17943136

Abstract

Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes. As a consequence, a loss or gain of Fox function can alter cell fate and promote tumorigenesis as well as cancer progression. Here we discuss the evidence that the deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer, and evaluate the emerging role of Fox proteins as direct and indirect targets for therapeutic intervention, as well as biomarkers for predicting and monitoring treatment responses.

摘要

叉头框（Fox）蛋白是一类进化上保守的转录调节因子超家族，它们控制着广泛的生物学过程。因此，Fox功能的丧失或获得可改变细胞命运，促进肿瘤发生及癌症进展。在此，我们讨论Fox家族转录因子失调在癌症发生和进展中起关键作用的证据，并评估Fox蛋白作为治疗干预的直接和间接靶点以及预测和监测治疗反应的生物标志物的新作用。