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用于亲脂性生物活性成分的乳液型递送系统。

Emulsion-based delivery systems for lipophilic bioactive components.

作者信息

McClements D J, Decker E A, Weiss J

机构信息

Dept. of Food Science, Univ. of Massachusetts, Amherst, MA 01003, USA.

出版信息

J Food Sci. 2007 Oct;72(8):R109-24. doi: 10.1111/j.1750-3841.2007.00507.x.

Abstract

There is a pressing need for edible delivery systems to encapsulate, protect, and release bioactive lipids within the food, medical, and pharmaceutical industries. The fact that these delivery systems must be edible puts constraints on the type of ingredients and processing operations that can be used to create them. Emulsion technology is particularly suited for the design and fabrication of delivery systems for encapsulating bioactive lipids. This review provides a brief overview of the major bioactive lipids that need to be delivered within the food industry (for example, omega-3 fatty acids, carotenoids, and phytosterols), highlighting the main challenges to their current incorporation into foods. We then provide an overview of a number of emulsion-based technologies that could be used as edible delivery systems by the food and other industries, including conventional emulsions, multiple emulsions, multilayer emulsions, solid lipid particles, and filled hydrogel particles. Each of these delivery systems could be produced from food-grade (GRAS) ingredients (for example, lipids, proteins, polysaccharides, surfactants, and minerals) using simple processing operations (for example, mixing, homogenizing, and thermal processing). For each type of delivery system, we describe its structure, preparation, advantages, limitations, and potential applications. This knowledge can be used to facilitate the selection of the most appropriate emulsion-based delivery system for specific applications.

摘要

在食品、医学和制药行业中,迫切需要可食用的递送系统来包裹、保护和释放生物活性脂质。这些递送系统必须是可食用的这一事实,对可用于制造它们的成分类型和加工操作施加了限制。乳液技术特别适合用于设计和制造用于包裹生物活性脂质的递送系统。本综述简要概述了食品工业中需要递送的主要生物活性脂质(例如,ω-3脂肪酸、类胡萝卜素和植物甾醇),突出了目前将它们纳入食品的主要挑战。然后,我们概述了一些可被食品和其他行业用作可食用递送系统的基于乳液的技术,包括常规乳液、多重乳液、多层乳液、固体脂质颗粒和填充水凝胶颗粒。这些递送系统中的每一种都可以使用简单的加工操作(例如,混合、均质化和热处理)由食品级(公认安全)成分(例如,脂质、蛋白质、多糖、表面活性剂和矿物质)生产。对于每种类型的递送系统,我们描述其结构、制备方法、优点、局限性和潜在应用。这些知识可用于促进为特定应用选择最合适的基于乳液的递送系统。

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