1960年至1990年间确诊的糖尿病儿童中HLA-DR3、-DR4、-B8和-Bw62的频率。

Frequencies of HLA-DR3, -DR4, -B8 and -Bw62 in diabetic children diagnosed between 1960 and 1990.

作者信息

Mäenpää A, Koskimies S, Scheinin T, Schlenzka A, Akerblom H K, Mäenpää J, Reunanen A, Kontiainen S

机构信息

Department of Pathology, University of Helsinki, Finland.

出版信息

Diabetes Res. 1991 Apr;16(4):159-63.

PMID:1802481

Abstract

An analysis of the HLA-types of 351 children in whom a diagnosis of insulin dependent diabetes mellitus (IDDM) had been made between 1960 and 1990 revealed that although the frequencies of HLA-DR3, -DR4, -DR3/4, -B8 and -Bw62 were increased there was, depending on the year of diagnosis, a marked fluctuation in the frequencies of these HLA-antigens and in the frequency with which -B8 was associated with -DR3 and -Bw62 with -DR4 suggesting heterogeneity/variation in agents initiating/triggering IDDM.

摘要

对1960年至1990年间被诊断为胰岛素依赖型糖尿病（IDDM）的351名儿童的HLA类型进行分析后发现，尽管HLA-DR3、-DR4、-DR3/4、-B8和-Bw62的频率有所增加，但根据诊断年份的不同，这些HLA抗原的频率以及-B8与-DR3、-Bw62与-DR4的关联频率存在显著波动，这表明引发IDDM的因素存在异质性/变异性。