用于喜树碱增溶的普朗尼克/聚乙二醇化维生素E琥珀酸酯混合胶束的制备与表征
Preparation and characterization of Pluronic/TPGS mixed micelles for solubilization of camptothecin.
作者信息
Gao Yan, Li Ling Bing, Zhai Guangxi
机构信息
Department of Pharmaceutics, School of Pharmacy, Shandong University, Jinan 250012, China.
出版信息
Colloids Surf B Biointerfaces. 2008 Jul 15;64(2):194-9. doi: 10.1016/j.colsurfb.2008.01.021. Epub 2008 Feb 5.
To increase the solubility and cytotoxicity of poorly soluble anticancer drug camptothecin (CPT), mixed micelles made of Pluronic P105 (P105) and d-alpha-tocopheryl polyethylene glycol 1,000 succinate (TPGS) were prepared. The interaction of Pluronic and TPGS was studied and critical micelle concentration (CMC) was used to evaluate the micellar stability towards dilution. Poorly soluble anticancer drug CPT was incorporated into the mixed micelles. The solubility of CPT by the mixed micelles was more than that of the free drug. The cytotoxicity of the CPT-loaded mixed micelles against MCF-7 cancer cell in vitro was remarkably higher than that of the free drug.
为提高难溶性抗癌药物喜树碱（CPT）的溶解度和细胞毒性，制备了由普朗尼克P105（P105）和聚乙二醇1000琥珀酸酯-α-生育酚（TPGS）组成的混合胶束。研究了普朗尼克和TPGS之间的相互作用，并使用临界胶束浓度（CMC）评估胶束对稀释的稳定性。将难溶性抗癌药物CPT载入混合胶束中。混合胶束对CPT的溶解度高于游离药物。载有CPT的混合胶束对MCF-7癌细胞的体外细胞毒性显著高于游离药物。
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