衰老过程中维持细胞稳态的FoxO转录因子。
FoxO transcription factors in the maintenance of cellular homeostasis during aging.
作者信息
Salih Dervis A M, Brunet Anne
机构信息
Department of Genetics, Stanford University, Stanford, CA 94305, United States.
出版信息
Curr Opin Cell Biol. 2008 Apr;20(2):126-36. doi: 10.1016/j.ceb.2008.02.005. Epub 2008 Apr 3.
Abstract
The FoxO family of Forkhead transcription factors functions at the interface of tumor suppression, energy metabolism, and organismal longevity. FoxO factors are key downstream targets of insulin, growth factor, nutrient, and oxidative stress stimuli that coordinate a wide range of cellular outputs. FoxO-dependent cellular responses include gluconeogenesis, neuropeptide secretion, atrophy, autophagy, apoptosis, cell cycle arrest, and stress resistance. This review will discuss the roles of the mammalian FoxO family in a variety of cell types, from stem cells to mature cells, in the context of the whole organism. Given the overwhelming evidence that the FoxO factors promote longevity in invertebrates, this review will also discuss the potential role of the FoxO factors in the aging of mammalian organisms.
摘要
叉头转录因子FoxO家族在肿瘤抑制、能量代谢和机体寿命方面发挥作用。FoxO因子是胰岛素、生长因子、营养物质和氧化应激刺激的关键下游靶点，可协调多种细胞输出。FoxO依赖的细胞反应包括糖异生、神经肽分泌、萎缩、自噬、凋亡、细胞周期停滞和应激抗性。本综述将在整个生物体的背景下，讨论哺乳动物FoxO家族在从干细胞到成熟细胞等多种细胞类型中的作用。鉴于有大量证据表明FoxO因子可促进无脊椎动物的寿命，本综述还将讨论FoxO因子在哺乳动物衰老过程中的潜在作用。
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