2006年从韩国南部水禽中分离出的禽流感病毒的基因特征分析

Genetic characterization of avian influenza viruses isolated from waterfowl in southern part of South Korea in 2006.

作者信息

Kim Heui Man, Oh Jung Hoon, Seo Sang Heui

机构信息

Laboratory of Influenza Research, Institute of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, South Korea.

出版信息

Virus Genes. 2008 Aug;37(1):49-51. doi: 10.1007/s11262-008-0230-4. Epub 2008 Apr 19.

DOI:10.1007/s11262-008-0230-4

PMID:18425571

Abstract

Aquatic birds are a reservoir of all known influenza A viruses. Avian influenza viruses have played a major role in the creation of pandemic influenza viruses in humans. In this study, we genetically characterized genes of nine isolates from waterfowl in Eulsukdo, a congregating place for migratory birds on the flyway of migration from Siberia, which is located in the southern part of South Korea. Phylogenic analysis showed that HA and NA genes of isolates belonged to Eurasian lineage, and lineage analysis showed that NS, PB1, PA, NP, and M genes of isolates clustered with Eurasian lineage, and PB2 genes of isolates belonged to North American or Eurasian lineage. Results suggest that the interregional transmission of genes of avian influenza viruses may occur in the migratory birds.

摘要

水鸟是所有已知甲型流感病毒的储存宿主。禽流感病毒在人类大流行性流感病毒的产生中发挥了重要作用。在本研究中，我们对来自于乙淑岛水禽的9株分离株的基因进行了遗传特征分析，乙淑岛是位于韩国南部的西伯利亚候鸟迁徙路线上的一个鸟类聚集地。系统发育分析表明，分离株的HA和NA基因属于欧亚谱系，谱系分析表明，分离株的NS、PB1、PA、NP和M基因与欧亚谱系聚类，而分离株的PB2基因属于北美或欧亚谱系。结果表明，禽流感病毒基因的区域间传播可能发生在候鸟中。