用于癌症体内光动力治疗的金纳米颗粒载体高效药物递送
Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer.
作者信息
Cheng Yu, C Samia Anna, Meyers Joseph D, Panagopoulos Irene, Fei Baowei, Burda Clemens
机构信息
Center for Chemical Dynamics and Nanomaterials Research, Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.
出版信息
J Am Chem Soc. 2008 Aug 13;130(32):10643-7. doi: 10.1021/ja801631c. Epub 2008 Jul 22.
Abstract
A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.
摘要
通过合成聚乙二醇化金纳米颗粒缀合物，开发了一种用于光动力疗法（PDT）药物递送的高效药物载体，该缀合物充当水溶性和生物相容性的“笼子”，可将疏水性药物递送至其PDT作用部位。在两相溶液系统中的体外和荷瘤小鼠体内的药物释放动力学表明，药物递送过程高效，且被动靶向优先作用于肿瘤部位。使用金纳米颗粒-叶绿素a 4缀合物时，PDT所需的药物递送时间已大幅缩短至不到2小时，而游离药物则需要2天。
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