槲皮素介导秀丽隐杆线虫的寿命延长：DAF-16是否参与其中？
Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?
作者信息
Saul Nadine, Pietsch Kerstin, Menzel Ralph, Steinberg Christian E W
机构信息
Humboldt-Universität zu Berlin, Department of Biology, Arboretum, Spaethstr. 80/81, 12437 Berlin, Germany.
出版信息
Mech Ageing Dev. 2008 Oct;129(10):611-3. doi: 10.1016/j.mad.2008.07.001. Epub 2008 Jul 23.
The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to increased mean lifespans up to 15%. Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance.
最近发现，多酚槲皮素可延长线虫秀丽隐杆线虫的寿命并增强其抗逆性。此前已发现叉头转录因子DAF-16与这些作用有关。然而，通过使用daf-16(mgDf50)突变株，我们发现暴露于槲皮素可使平均寿命延长高达15%。此外，经槲皮素处理的daf-16(mgDf50)线虫对热应激和氧化应激的抵抗力增强。我们的数据表明，DAF-16并非槲皮素介导的长寿和抗逆性所必需的。
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