代谢综合征：从流行病学到系统生物学
Metabolic syndrome: from epidemiology to systems biology.
作者信息
Lusis Aldons J, Attie Alan D, Reue Karen
机构信息
Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
出版信息
Nat Rev Genet. 2008 Nov;9(11):819-30. doi: 10.1038/nrg2468.
Abstract
Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote the development of cardiovascular disease (CVD) and diabetes. Recent genome-wide association studies have identified several novel susceptibility genes for MetSyn traits, and studies in rodent models have provided important molecular insights. However, as yet, only a small fraction of the genetic component is known. Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn.
摘要
代谢综合征（MetSyn）是一组共同出现并促进心血管疾病（CVD）和糖尿病发展的代谢状况。最近的全基因组关联研究已经确定了几个与代谢综合征特征相关的新的易感基因，并且在啮齿动物模型中的研究提供了重要的分子见解。然而，到目前为止，已知的遗传成分仅占一小部分。整合基因组、分子和生理数据的基于系统的方法正在补充传统的遗传和生化方法，以更全面地应对代谢综合征的复杂性。
相似文献
1
Metabolic syndrome: from epidemiology to systems biology.
Nat Rev Genet. 2008 Nov;9(11):819-30. doi: 10.1038/nrg2468.
2
Genetics of glucose homeostasis: implications for insulin resistance and metabolic syndrome.
Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2091-6. doi: 10.1161/ATVBAHA.112.255463.
3
Genetics of Insulin Resistance and the Metabolic Syndrome.
Curr Cardiol Rep. 2016 Aug;18(8):75. doi: 10.1007/s11886-016-0755-4.
4
Genetics of metabolic syndrome.
Rev Endocr Metab Disord. 2014 Dec;15(4):243-52. doi: 10.1007/s11154-014-9293-9.
5
Relationship between Vitamin D Receptor gene polymorphisms and the components of metabolic syndrome.
Nutr J. 2013 Jul 15;12:96. doi: 10.1186/1475-2891-12-96.
6
Combined effects of the C161T and Pro12Ala PPARγ2 gene variants with insulin resistance on metabolic syndrome: a case-control study of a central Tunisian population.
J Mol Neurosci. 2014 Apr;52(4):487-92. doi: 10.1007/s12031-013-0161-y. Epub 2013 Nov 19.
7
The investigations of genetic determinants of the metabolic syndrome.
Diabetes Metab Syndr. 2018 Sep;12(5):783-789. doi: 10.1016/j.dsx.2018.04.009. Epub 2018 Apr 11.
8
The Genetic Variants Influencing Hypertension Prevalence Based on the Risk of Insulin Resistance as Assessed Using the Metabolic Score for Insulin Resistance (METS-IR).
Int J Mol Sci. 2024 Nov 26;25(23):12690. doi: 10.3390/ijms252312690.
9
Association of common genetic variants with diabetes and metabolic syndrome related traits in the Arizona Insulin Resistance registry: a focus on Mexican American families in the Southwest.
Hum Hered. 2014;78(1):47-58. doi: 10.1159/000363411. Epub 2014 Jul 8.
10
Risk Factors for Insulin Resistance, Metabolic Syndrome, and Diabetes in 248 HFE C282Y Homozygotes Identified by Population Screening in the HEIRS Study.
Metab Syndr Relat Disord. 2016 Mar;14(2):94-101. doi: 10.1089/met.2015.0123. Epub 2016 Jan 15.
引用本文的文献
1
Adipocyte-specific Krüppel-like factor 14 overexpression confers sex-biased protection from weight gain on a high-fat diet.
Physiol Rep. 2025 Aug;13(15):e70513. doi: 10.14814/phy2.70513.
2
A 12-week consumer wearable activity tracker-based intervention reduces sedentary behaviour and improves cardiometabolic health in free-living sedentary adults: a randomised controlled trial.
J Act Sedentary Sleep Behav. 2022 Dec 1;1(1):8. doi: 10.1186/s44167-022-00007-z.
3
Microfluidics-Based Microcarriers for Live-Cell Delivery.
Adv Sci (Weinh). 2025 May;12(18):e2414410. doi: 10.1002/advs.202414410. Epub 2025 Apr 4.
4
Involvement of Megasphaera in the oral microbiome and dyslipidemia onset: evidence from a community-based study in Japan.
Folia Microbiol (Praha). 2025 Apr 2. doi: 10.1007/s12223-025-01258-4.
5
Targeting the Gut-Heart Axis Improves Cardiac Remodeling in a Clinical Scale Model of Cardiometabolic Syndrome.
JACC Basic Transl Sci. 2024 Nov 20;10(1):1-15. doi: 10.1016/j.jacbts.2024.09.004. eCollection 2025 Jan.
6
Sex-specific impact of rs1260326 polymorphism on metabolic traits in an older Japanese population: the Bunkyo Health Study.
Ther Adv Endocrinol Metab. 2024 Sep 27;15:20420188241280540. doi: 10.1177/20420188241280540. eCollection 2024.
7
Metformin Regulates Cardiac Ferroptosis to Reduce Metabolic Syndrome-Induced Cardiac Dysfunction.
Appl Biochem Biotechnol. 2025 Jan;197(1):179-193. doi: 10.1007/s12010-024-05038-7. Epub 2024 Aug 6.
8
Modulatory Roles of , , , and Gene Expression in Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes.
Viruses. 2024 Jun 19;16(6):985. doi: 10.3390/v16060985.
9
Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity.
iScience. 2024 Feb 26;27(3):109121. doi: 10.1016/j.isci.2024.109121. eCollection 2024 Mar 15.
10
Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors.
Commun Med (Lond). 2024 Mar 16;4(1):50. doi: 10.1038/s43856-024-00474-2.
本文引用的文献
1
The emerging genetic architecture of type 2 diabetes.
Cell Metab. 2008 Sep;8(3):186-200. doi: 10.1016/j.cmet.2008.08.006.
2
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.
Diabetes. 2008 Nov;57(11):3112-21. doi: 10.2337/db08-0516. Epub 2008 Aug 4.
3
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.
Nat Genet. 2008 Aug;40(8):952-4. doi: 10.1038/ng.164. Epub 2008 Jun 29.
4
Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome.
Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1225-36. doi: 10.1161/ATVBAHA.107.160192.
5
New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function.
Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):371-7. doi: 10.1097/MCO.0b013e32830349a1.
6
Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney.
J Clin Invest. 2008 Jul;118(7):2526-34. doi: 10.1172/JCI33293.
7
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
J Clin Invest. 2008 Jul;118(7):2620-8. doi: 10.1172/JCI34566.
8
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy.
J Lipid Res. 2008 Oct;49(10):2101-12. doi: 10.1194/jlr.M800147-JLR200. Epub 2008 May 30.
9
Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes.
Diabetes. 2008 Sep;57(9):2461-9. doi: 10.2337/db07-1808. Epub 2008 May 28.
10
High-fat diets cause insulin resistance despite an increase in muscle mitochondria.
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7815-20. doi: 10.1073/pnas.0802057105. Epub 2008 May 28.
Zotero 插件