蛋白激酶A作为癌症治疗中的生物学靶点。
Protein kinase A as a biological target in cancer therapy.
作者信息
Naviglio Silvio, Caraglia Michele, Abbruzzese Alberto, Chiosi Emilio, Di Gesto Davide, Marra Monica, Romano Maria, Sorrentino Annunziata, Sorvillo Luca, Spina Annamaria, Illiano Gennaro
机构信息
Second University of Naples, Medical School, Department of Biochemistry and Biophysics, Via L. De Crecchio 7, 80138 Naples, Italy.
出版信息
Expert Opin Ther Targets. 2009 Jan;13(1):83-92. doi: 10.1517/14728220802602349.
BACKGROUND
cAMP is a second messenger that plays a role in intracellular signal transduction of various stimuli. a major function of cAMP in eukaryotes is activation of cAMP-dependent protein kinase (PKA). PKA is the best understood member of the serine-threonine protein kinase superfamily, and is involved in the control of a variety of cellular processes. since it has been implicated in the initiation and progression of many tumors, PKA has been suggested as a novel molecular target for cancer therapy.
OBJECTIVE/METHODS: Here, after describing some features of cAMP/PKA signaling that are relevant to cancer biology, we review targeting of PKA in cancer therapy, also discussing PKA as a biomarker for cancer detection and monitoring of therapy.
RESULTS/CONCLUSIONS: PKA is an increasingly relevant biological target in the therapy and management of cancer.
背景
环磷酸腺苷（cAMP）是一种第二信使，在多种刺激的细胞内信号转导中发挥作用。cAMP在真核生物中的一个主要功能是激活环磷酸腺苷依赖性蛋白激酶（PKA）。PKA是丝氨酸 - 苏氨酸蛋白激酶超家族中了解最清楚的成员，参与多种细胞过程的调控。由于它与许多肿瘤的发生和发展有关，PKA已被建议作为癌症治疗的新型分子靶点。
目的/方法：在此，在描述了一些与癌症生物学相关的cAMP/PKA信号传导特征后，我们综述了PKA在癌症治疗中的靶向作用，还讨论了PKA作为癌症检测和治疗监测生物标志物的情况。
结果/结论：PKA在癌症治疗和管理中是一个越来越重要的生物学靶点。
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