脊髓性肌萎缩症中白细胞与脊髓中存活运动神经元表达的相关性
Correlation of survival motor neuron expression in leukocytes and spinal cord in spinal muscular atrophy.
作者信息
Tsai Li-Kai, Yang Chih-Chao, Ting Chen-Hung, Su Yi-Ning, Hwu Wuh-Liang, Li Hung
机构信息
Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
出版信息
J Pediatr. 2009 Feb;154(2):303-5. doi: 10.1016/j.jpeds.2008.08.050.
PMID:19150680
Abstract
Survival motor neuron (SMN) messenger RNA and protein levels in spinal muscular atrophy (SMA) model mice and in patients with SMA were measured. There was a high correlation between leukocyte and spinal cord SMN expression in SMA model mice and a moderate correlation between leukocyte SMN expression and age of disease onset in patients with SMA.
摘要
对脊髓性肌萎缩症（SMA）模型小鼠和SMA患者的存活运动神经元（SMN）信使核糖核酸及蛋白质水平进行了测量。在SMA模型小鼠中，白细胞与脊髓SMN表达之间存在高度相关性；在SMA患者中，白细胞SMN表达与疾病发病年龄之间存在中度相关性。
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