Zilberberg Marya D, Shorr Andrew F
Department of Health Policy and Management, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts 01032, USA.
Semin Respir Crit Care Med. 2009 Feb;30(1):10-5. doi: 10.1055/s-0028-1119804. Epub 2009 Feb 6.
Healthcare-associated pneumonia (HCAP) represents a distinct syndrome, separate from both community-acquired pneumonia (CAP) and nosocomial pneumonia. Although patients with HCAP present from the community, the epidemiology and bacteriology of HCAP belie the community label. As such, highly resistant pathogens such as methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa are commonly seen in HCAP. Although the true prevalence of HCAP is unclear the proportion of pneumonias admitted to the hospital due to HCAP relative to CAP appears to be increasing. The attendant mortality of HCAP is higher than that reported in CAP and approximates that seen in hospital-acquired pneumonia (HAP). More precise instruments are needed to heighten clinicians' index of suspicion for treating probable resistant pathogens with appropriate empirical antibiotic choices.
医疗保健相关肺炎(HCAP)是一种独特的综合征,既不同于社区获得性肺炎(CAP),也不同于医院获得性肺炎。尽管HCAP患者来自社区,但HCAP的流行病学和细菌学情况却与社区这一标签不符。因此,耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌等高度耐药病原体在HCAP中很常见。虽然HCAP的真实患病率尚不清楚,但因HCAP入院的肺炎患者相对于CAP患者的比例似乎在增加。HCAP的伴发死亡率高于CAP报告的死亡率,接近医院获得性肺炎(HAP)的死亡率。需要更精确的工具来提高临床医生对使用适当经验性抗生素治疗可能的耐药病原体的怀疑指数。