脊椎动物初级纤毛在发育、稳态及疾病中的作用
The vertebrate primary cilium in development, homeostasis, and disease.
作者信息
Gerdes Jantje M, Davis Erica E, Katsanis Nicholas
机构信息
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Cell. 2009 Apr 3;137(1):32-45. doi: 10.1016/j.cell.2009.03.023.
Abstract
Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction.
摘要
纤毛是复杂的结构，因其在脊椎动物发育中的作用以及与人类遗传疾病的关联而备受关注。与纤毛仅限于特定细胞类型的多细胞无脊椎动物不同，这些细胞器在脊椎动物细胞中几乎普遍存在，在那里它们发挥着多种信号传导功能。在这里，我们重点介绍脊椎动物纤毛的特性，特别强调它们与其他亚细胞结构的关系，并探讨纤毛功能障碍的生理后果。
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