1995 年至 2006 年波斯尼亚和黑塞哥维那图兹拉地区溃疡性结肠炎：流行病学和临床特征。

Ulcerative colitis in the Tuzla region of Bosnia and Herzegovina between 1995 and 2006: epidemiological and clinical characteristics.

机构信息

Department of Gastroenterology, Internal Medicine Hospital, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.

出版信息

Eur J Gastroenterol Hepatol. 2010 Mar;22(3):346-53. doi: 10.1097/MEG.0b013e32832bfe05.

DOI:10.1097/MEG.0b013e32832bfe05

PMID:19474740

Abstract

BACKGROUND

Bosnia and Herzegovina (B&H) is one of the Eastern European countries that lacks data on the epidemiology of ulcerative colitis (UC).

AIMS

We aimed to assess the epidemiological and clinical characteristics of UC in Tuzla Canton of B&H during a 12-year period (1995-2006).

PATIENTS AND METHODS

We retrospectively evaluated hospital records of both UC inpatients and outpatients residing in Tuzla Canton of B&H (total of 496 280 inhabitants) between 1995 and 2006. Patients that firmly satisfied the diagnostic criteria for UC were included in the study. Incidence rates were calculated with age standardization using European population standards. Trends in incidence were evaluated as moving 3-year averages.

RESULTS

During the observed period, 214 patients met the diagnostic criteria for UC. The average age-standardized incidence was found to be 3.43/10 inhabitants [95% confidence interval (CI) = 2.97-3.89], ranging from 0.22 to 7.44 per 10. The mean annual crude incidence in the last 5 years of study (2002-2006) was 5.55/10 (95% CI = 4.63-6.48). The prevalence of UC during the observed period was found to be 43.1/10 (95% CI = 37.3-48.8). The incidence of UC increased dramatically from the average of 1.01/10 in the period between 1995 and 1997 to 6.04/10 between 2004 and 2006, as did the number of colonoscopies performed, from 29 in 1995 to 850 in 2006. The average yearly incidence of confirmed UC cases detected on colonoscopy was 5.56 per 100 colonoscopies per year (95% CI = 4.81-6.30) and only 3.92 per 100 colonoscopies (95% CI = 3.26-4.57) in the last 5 years of the observed period.

CONCLUSION

Tuzla Canton of B&H is a region with an increasing incidence of UC, which is most likely a direct consequence of a wider use of colonoscopy. We believe that in the next few years, the incidence of UC in this region will probably reach the annual incidence rate of 6 per 10 inhabitants.

摘要

背景

波斯尼亚和黑塞哥维那（波黑）是东欧国家之一，缺乏溃疡性结肠炎（UC）流行病学数据。

目的

我们旨在评估波黑图兹拉州 12 年间（1995-2006 年）UC 的流行病学和临床特征。

患者和方法

我们回顾性评估了 1995 年至 2006 年间居住在波黑图兹拉州（总人口为 496280 人）的 UC 住院和门诊患者的医院记录。我们将符合 UC 诊断标准的患者纳入研究。发病率通过使用欧洲人口标准进行年龄标准化计算。发病率趋势评估为移动 3 年平均值。

结果

在观察期间，有 214 名患者符合 UC 的诊断标准。平均年龄标准化发病率为 3.43/10 居民[95%置信区间（CI）=2.97-3.89]，范围为 0.22 至 7.44/10。研究最后 5 年（2002-2006 年）的平均年度粗发病率为 5.55/10（95%CI=4.63-6.48）。观察期间 UC 的患病率为 43.1/10（95%CI=37.3-48.8）。UC 的发病率从 1995 年至 1997 年期间的平均 1.01/10 急剧上升至 2004 年至 2006 年期间的 6.04/10，结肠镜检查数量也从 1995 年的 29 次增加到 2006 年的 850 次。每年通过结肠镜检查确诊的 UC 病例平均发病率为每年每 100 次结肠镜检查 5.56 例（95%CI=4.81-6.30），而在观察期最后 5 年期间仅为每 100 次结肠镜检查 3.92 例（95%CI=3.26-4.57）。